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Mechanisms of transplantation tolerance in animals and humans

Megan Sykes1

  • 1Bone Marrow Transplantation Section, Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA. megan.sykes@tbrc.mgh.harvard.edu

Transplantation
|May 9, 2009
PubMed

Donor-specific immune tolerance would avoid the toxicities of chronic immunosuppressive therapies while preventing graft rejection. Hematopoietic cell transplantation has shown preliminary success for intentional tolerance induction in pilot clinical trials. The mechanisms of tolerance in these trials and the animal studies leading up to them are discussed.

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