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[Factors associated with Hepatitis C infection in patients with chronic hemodyalisis]
Magda Valencia Yábar1, Javier Cieza Zevallos
1Centro de Hemodialisis - EsSalud, Peru.
Insights
Hepatitis C virus (HCV) infection in hemodialysis patients in Peru is linked to longer dialysis duration, multiple hospitalizations, transplants, and blood transfusions. These factors highlight key areas for prevention strategies in chronic kidney disease patients undergoing dialysis.
Area of Science:
- Nephrology
- Infectious Diseases
- Epidemiology
Context:
- Hepatitis C Virus (HCV) poses a significant health challenge for patients undergoing chronic hemodialysis in Peru.
- Previous research identified blood transfusions and duration on hemodialysis as risk factors for HCV infection.
Purpose:
- To investigate additional potential risk factors associated with Hepatitis C virus infection among a large hemodialysis population in Lima, Peru.
- To identify modifiable and non-modifiable factors contributing to HCV transmission in this vulnerable patient group.
Summary:
- A case-control study analyzed incident populations, comparing positive HCV antibody cases with matched negative controls.
- Key factors associated with HCV infection included extended time on hemodialysis, multiple hospitalizations, treatment at various dialysis centers, prior transplantation, and history of blood transfusions.
Impact:
- Findings underscore the importance of comprehensive screening and infection control measures in hemodialysis centers.
- Identified risk factors can inform targeted interventions to reduce HCV transmission and improve patient outcomes in chronic kidney disease populations.
Background:
Hepatitis C Infection (HCV) is a significant problem in patients treated with chronic hemodialysis in Peru. In prior studies, it has been reported that blood transfusions and time on hemodialysis have been identified as risk factors.
Purpose:
Study other probable factors associated with the Hepatitis C virus in a large hemodyalisis center in Lima, Peru.
Materials And Method:
The study consisted of a case model and controls for incident population. A negative case was studied in relation to each case with positive results for HCV antibodies paired by age, sex and origin. Odds ratio (OR) and its confidence interval (CI 95%) were used to assess the degree of association between variables.
Results:
Time on hemodialysis (OR 7.13, CI 95%), 3.04-17.02), more than two hospitalizations (OR 4.49, CI 95%), 1.28-17.28), treatment in multiple dialysis centers (p<0.5), having undergone a transplant (p<0.01) and having received a blood transfusion (OR 2.61 CI 95% 1.04-6.68) were factors associated with HCV.
Conclusion:
Permanence on hemodialysis, hospitalizations, receiving dialysis at multiple centers, transplantation and blood transfusions were variables associated with HCV infection in the studied population.
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