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Updated: Jun 23, 2026
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Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
Published on: February 14, 2021
ANALYSIS OF BAROREFLEX FUNCTION BY MEANS OF MATHEMATICAL MODEL
B Fišer1, J Siegelová, M Pohanka
1Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Scripta Medica
|May 9, 2009
Summary
The baroreflex regulates blood pressure and volume, working alongside the kidneys. Mathematical modeling shows cardiac output significantly decreases after baroreceptor denervation.
Area of Science:
- Physiology
- Mathematical Modeling
- Cardiovascular System
Background:
- The baroreflex is crucial for short-term blood pressure regulation.
- Its precise roles in conjunction with other systems, like the kidneys, require further elucidation.
Purpose of the Study:
- To re-evaluate baroreflex functions using a simplified mathematical model of circulation.
- To investigate the impact of baroreceptor denervation on cardiovascular regulation during rest and exercise.
Main Methods:
- Development of a mathematical model simulating circulatory states.
- Modeling included rest, immediate post-denervation, delayed post-denervation, pre-denervation exercise, and post-denervation exercise.
Main Results:
- Cardiac output was reduced by one-third following baroreceptor denervation, even with maintained cardiac contractility and muscle vasodilatation.
- Model simulations quantified the effects of denervation on circulatory parameters.
Conclusions:
- The baroreflex plays a primary role in the coordinated regulation of blood pressure and blood volume, in conjunction with renal function.
- Mathematical modeling provides valuable insights into complex physiological regulatory mechanisms.
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