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Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

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Related Experiment Video

Updated: Jun 23, 2026

Sub-Retinal Delivery of Human Embryonic Stem Cell Derived Photoreceptor Progenitors in rd10 Mice
07:46

Sub-Retinal Delivery of Human Embryonic Stem Cell Derived Photoreceptor Progenitors in rd10 Mice

Published on: October 6, 2023

Stem-cell therapy in retinal disease.

Paul S Baker1, Gary C Brown

  • 1Retina Service, Wills Eye Institute, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA. pbakerny@yahoo.com

Current Opinion in Ophthalmology
|May 9, 2009
PubMed
Summary
This summary is machine-generated.

Stem cell therapy shows promise for treating retinal diseases by replacing damaged cells and restoring vision. Ongoing research aims to improve cell integration and function for better patient outcomes.

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Last Updated: Jun 23, 2026

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Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model
07:43

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Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Neuroscience

Background:

  • Stem cell research offers potential treatments for previously untreatable retinal diseases.
  • Cell replacement strategies are being explored to restore vision in patients with severe vision loss.

Purpose of the Study:

  • To review the current progress in stem cell therapy for retinal diseases.
  • To identify obstacles hindering the clinical application of stem cell treatments for retinal conditions.

Main Methods:

  • Review of studies investigating stem cell transplantation in retinal disease models.
  • Analysis of different stem cell types, including embryonic, neural, mesenchymal, and retinal stem cells.
  • Evaluation of stem cell survival, differentiation, integration, and functional recovery.

Main Results:

  • Stem cell transplants demonstrate survival, migration, differentiation, and integration within the retina.
  • Transplanted cells exhibit retina-like morphology and phenotype, with evidence of synaptic reconnection.
  • Studies in animal models and humans show potential for visual recovery.

Conclusions:

  • Stem cell therapy is a promising approach for vision restoration in retinal diseases.
  • Further research is needed to optimize cell yield and integration for clinical success.