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The receptor RAGE: Bridging inflammation and cancer

Astrid Riehl1, Julia Németh, Peter Angel

  • 1German Cancer Research Center, DKFZ-ZMBH Alliance, Division of Signal Transduction and Growth Control (A100), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. p.angel@dkfz-heidelberg.de.

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Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Activation of Integrins

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The Tumor Microenvironment

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Signal Transduction: Overview

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Typically, signal transduction involves three...
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Interactions Between Signaling Pathways

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Convergence and divergence, and cross-talk between signaling pathways
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