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Updated: Jun 23, 2026

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
Chronic basophilic leukemia: a rare form of chronic myeloproliferative neoplasm
Guilin Tang1, Lesley J Woods, Sa A Wang
1Department of Pathology, University of Massachusetts Medical Center, Worcester, MA 01605, USA.
Abstract:
Chronic basophilic leukemia is a rare and poorly characterized entity. Only a limited number of cases have been described. Herein, we report a patient who presented with fatigue, weight loss, leukocytosis, persistent prominent basophilia, and mild eosinophilia. The bone marrow showed features characteristic of a myeloproliferative neoplasm with a marked increase in maturing basophils. The basophils exhibited nuclear hypersegmentation, abnormal granulation, and abnormally low CD38 expression. Conventional karyotyping revealed a t(5;12)(q31;p13). ETV6 but not PDGFRB rearrangement was detected by fluorescence in situ hybridization.
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