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Hypertension III: Clinical Manifestations and Diagnostic Studies

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Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...

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Updated: Jun 23, 2026

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis

Published on: September 26, 2018

Hypertension: reflections on risks and prognostication.

William B Kannel¹

¹Boston University School of Medicine/Framingham Heart Study, Framingham, MA 01702-5827, USA. billkannel@yahoo.com

The Medical Clinics of North America

|May 12, 2009

Summary

The Framingham Heart Study identified elevated blood pressure as a key cardiovascular risk factor. This research advanced preventive cardiology and led to hypertension treatments and public health campaigns.

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Last Updated: Jun 23, 2026

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis

Published on: September 26, 2018

Area of Science:

Epidemiology
Cardiology
Public Health

Background:

The Framingham Heart Study is a cornerstone of cardiovascular disease research.
Understanding cardiovascular risk factors is crucial for preventive cardiology.

Purpose of the Study:

To highlight the role of the Framingham Heart Study in cohort research.
To emphasize the multifactorial nature of coronary heart disease (CHD).
To underscore the significance of elevated blood pressure as a cardiovascular risk factor.

Main Methods:

Prospective population-based epidemiologic research.
Longitudinal cohort study design.
Analysis of cardiovascular disease risk factors.

Main Results:

No single factor fully explains coronary heart disease (CHD) risk; multiple factors are involved.
Elevated blood pressure is a prominent cardiovascular risk factor.
The study demonstrated a strong association between blood pressure and cardiovascular events.

Conclusions:

The Framingham Heart Study significantly advanced cohort study design and preventive cardiology.
Research findings on blood pressure spurred pharmaceutical development for hypertension control.
The study's impact includes national campaigns against hypertension and its vascular consequences.