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Published on: February 9, 2021
Changes in urinary lithogenic features over time in patients with urolithiasis.
Yong-June Kim1, Yun-Sok Ha, Sung-Whan Jo
1Department of Urology, Chungbuk National University College of Medicine, Cheongju, Chungbuk, South Korea.
Urology
|May 12, 2009
Summary
Urinary metabolic risk factors for calcium stones have changed over time, with increased hyperuricosuria observed in recent years, particularly in men. This rise in hyperuricosuria may be linked to a higher incidence of obesity in male patients with stone formation.
Area of Science:
- Nephrology
- Urology
- Metabolic Medicine
Background:
- Urinary metabolic risk factors are crucial in calcium stone formation (SF).
- Understanding temporal trends and sex-specific differences in these factors is essential for effective prevention and treatment strategies.
- Previous studies have not fully elucidated the evolving patterns of urinary lithogenic factors in specific populations.
Purpose of the Study:
- To assess temporal changes in urinary metabolic risk factors for calcium stone formation.
- To investigate sex-specific differences in these evolving risk factors.
- To identify trends in metabolic abnormalities associated with kidney stone disease.
Main Methods:
- Retrospective analysis of 619 patients with first-time calcium stone formation.
- Patients were categorized into two groups based on diagnosis date: 1994-1999 (Group 1) and 2000-2007 (Group 2).
- Complete metabolic assessments were performed for all patients.
Main Results:
- Obesity incidence increased significantly in Group 2, especially among male patients with SF.
- Lower urinary pH, reduced total urine volume, and increased uric acid excretion were observed in Group 2 compared to Group 1.
- Hyperuricosuria incidence rose in men with SF in Group 2, but no significant difference was found in women.
Conclusions:
- The pattern of urinary lithogenic factors in Korean patients with SF has evolved over time.
- Hyperuricosuria has become more prevalent, particularly in men, potentially linked to increased obesity.
- These findings highlight the need for updated clinical guidelines for managing kidney stone disease.
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