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This study analyzed 219 children with primary peritonitis, finding immune system disorders and a link to genital maturation in girls. All patients underwent successful surgical treatment.
Area of Science:
- Pediatric Surgery
- Immunology
- Infectious Diseases
Context:
- Primary peritonitis in children is a serious condition.
- This study focuses on a cohort of 219 pediatric patients.
- The analysis includes both simple and toxic forms of the disease.
Purpose:
- To analyze the treatment outcomes for children with primary peritonitis.
- To identify immunological factors associated with primary peritonitis.
- To investigate potential correlations between primary peritonitis and genital maturation in female patients.
Summary:
- The study reviewed 219 pediatric cases of primary peritonitis, predominantly in children under seven years old.
- Significant immune dysfunctions, including humoral (B-system) and cellular (T-system) immunity, were observed.
- A notable correlation was found between primary peritonitis and genital maturation in 72% of affected girls.
- All patients received surgical treatment with positive recovery outcomes.
Impact:
- Highlights the immunological vulnerabilities in children with primary peritonitis.
- Suggests a potential link between reproductive system development and peritonitis risk in girls.
- Provides insights into surgical management and recovery in pediatric primary peritonitis cases.
Abstract:
The results of treatment of 219 children with "primary peritonitis" are analysed. Most patients (73.5%) were under 7 years of age. The simple form of primary peritonitis was encountered in 158 (72.1%) and the toxic form in 61 (27.9%) patients. Significant disorders of humoral (B-system) and cellular (T-system) immunity as well as combined incompetence of the neutrophil intra-leukocytic microbicidal system were revealed. In 72% of girls a relation was detected between the occurrence of primary peritonitis and the condition of maturation of the genitalia. All the children were treated by operation and recovered.