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Use of an Influenza Antigen Microarray to Measure the Breadth of Serum Antibodies Across Virus Subtypes
Published on: July 26, 2019
Evidence of effectiveness from a large county-wide school-based influenza immunization campaign
Carlos G Grijalva1, Yuwei Zhu, Marie R Griffin
1Department of Preventive Medicine, Vanderbilt University School of Medicine, 1500 21st Avenue Suite 2600, The Village at Vanderbilt, Nashville, TN 37232-2637, United States. carlos.grijalva@vanderbilt.edu
Abstract:
A school-based campaign in Knox County, TN immunized 41% and 48% of school children with live attenuated influenza vaccine in 2005 and 2006, respectively. We computed the relative risk (RR) of a positive rapid influenza test in Knox compared to Knox-surrounding county children (controls) during five baseline and two campaign seasons. Among children aged <5 years, the RR for a positive test remained relatively constant throughout the study seasons. Among children aged 5-17 years (target population), the RR was 1 during baseline and declined by 21% (RR, 0.79; 95% CI, 0.59-1.05) and 27% (RR, 0.73; 95% CI, 0.60-0.87) during the first and second campaign season, respectively. These findings suggest a direct beneficial effect of the immunization campaign.
