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Short-term changes in drug agglomeration within interactive mixtures following blending.

J G Andreou1, P J Stewart, D A V Morton

  • 1Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Science, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.

International Journal of Pharmaceutics
|May 12, 2009
PubMed
Summary

Drug dissolution rates in interactive mixtures decrease significantly after blending due to increased particle agglomeration. This study highlights the need for better understanding of powder behavior in drug delivery systems.

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