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Updated: Jun 23, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
Published on: July 16, 2017
FlexServ: an integrated tool for the analysis of protein flexibility
Jordi Camps1, Oliver Carrillo, Agustí Emperador
1Joint IRB-BSC Program on Computational Biology, Institute of Research in Biomedicine, Barcelona Science Park, Josep Samitier 1-5, Barcelona, Spain.
FlexServ is a web tool for analyzing protein flexibility using Normal Mode Analysis (NMA), Brownian dynamics (BD), and Discrete Dynamics (DMD). It provides comprehensive flexibility metrics and visualizations for detailed protein dynamics studies.
Area of Science:
- Computational Biology
- Structural Bioinformatics
- Molecular Dynamics
Background:
- Protein flexibility is crucial for biological function.
- Analyzing protein dynamics requires specialized computational tools.
Purpose of the Study:
- To introduce FlexServ, a web-based server for protein flexibility analysis.
- To provide a comprehensive platform for studying protein dynamics.
Main Methods:
- Utilizes coarse-grained Normal Mode Analysis (NMA), Brownian dynamics (BD), and Discrete Dynamics (DMD).
- Supports analysis of user-provided molecular dynamics trajectories.
- Incorporates a wide array of flexibility metrics.
Main Results:
- FlexServ offers detailed analysis including B-factors, essential dynamics, and residue correlations.
- Provides tools for dynamic domain and hinge point detection.
- Presents data through an interactive web interface with 2D and 3D graphics.
Conclusions:
- FlexServ is a versatile tool for in-depth protein flexibility and dynamics analysis.
- The server facilitates a comprehensive understanding of protein conformational changes.
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