Related Experiment Video
Updated: Jun 23, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
Published on: July 6, 2013
Cytomegalovirus infection in six neonates
Abstract:
Neonatal cytomegalovirus (CMV) infection is common, has myriad presentations and severe sequelae. Six neonates clinically suspected of CMV infection were confirmed by qualitative PCR (Digene) and evaluated. Those with persistent viremia were treated with Ganciclovir intravenously for 4-6 weeks, and continued orally, if required, with close monitoring. All had prolonged jaundice, hepatosplenomegaly and hematological manifestations in the acute stage. Complications included developmental delay (66%), sensorineural hearing loss (SNHL) (33%), chorioretinitis and obstructive jaundice (18% each). Three cleared viremia spontaneously. The remaining were offered Ganciclovir. One declined, and two completed therapy with clinical resolution and no adverse events. Accurate diagnosis of neonatal CMV enables appropriate treatment with Ganciclovir, which can reverse end-organ damage and limit sequelae.
More Related Videos
05:51Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
Published on: July 24, 2016
08:08qPCR Is a Sensitive and Rapid Method for Detection of Cytomegaloviral DNA in Formalin-fixed, Paraffin-embedded Biopsy Tissue
Published on: July 9, 2014
Related Concept Videos
Cytomegalovirus Disease
Respiratory Syncytial Virus Disease
Cryptococcal Meningitis
Viral Meningitis
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Poliomyelitis