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Updated: Jun 23, 2026
07:29
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
[Therapeutic options in vernal keratoconjunctivitis].
1Augenklinik der Ludwig-Maximilians-Universität München, München, Deutschland. emessmer@med.uni-muenchen.de
Summary
Vernal keratoconjunctivitis (VKC) is a complex allergic eye inflammation involving T-cells and immune reactions. Current treatments manage symptoms, while new therapies targeting specific pathways are under investigation.
Area of Science:
- Ophthalmology
- Immunology
- Allergy
Context:
- Vernal keratoconjunctivitis (VKC) is a chronic allergic eye condition.
- It presents seasonal exacerbations affecting eyelids, conjunctiva, and cornea.
Purpose:
- To elucidate the complex pathogenetic mechanisms of VKC beyond simple hypersensitivity.
- To review current and emerging therapeutic strategies for VKC management.
Summary:
- VKC pathogenesis involves T-cell responses, eosinophil recruitment, and non-specific immune reactions.
- Key mediators include cytokines, chemokines, proteases, and growth factors.
- Established treatments include mast cell stabilizers, antihistamines, corticosteroids, and immunosuppressants.
Impact:
- Understanding VKC's complex immunology informs the development of targeted therapies.
- Emerging treatments like antichemokine receptor antibodies and leukotriene antagonists offer more selective approaches.
- This research aids in improving long-term management and patient outcomes for VKC.
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