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Related Experiment Video

Updated: Jun 23, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

[Depressive disorders in patients after stroke].

E I Gusev, A N Bogolepova

    Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
    |May 12, 2009
    PubMed
    Summary

    Citalopram (opra) effectively treats post-stroke depression, improving quality of life and recovery. This antidepressant also offers anxiolytic benefits with minimal side effects and no negative impact on daily functioning.

    Area of Science:

    • Neurology
    • Psychiatry
    • Pharmacology

    Background:

    • Post-stroke depression significantly impacts patient recovery and quality of life.
    • Ischemic stroke survivors are at high risk for developing depression.
    • Effective treatment for post-stroke depression is crucial for improved prognosis.

    Purpose of the Study:

    • To evaluate the efficacy of citalopram (Opra) in treating post-stroke depression.
    • To assess the anxiolytic effects of citalopram in this patient population.
    • To determine the safety and tolerability of citalopram regarding daily activities and cognitive function.

    Main Methods:

    • Clinical study assessing the efficacy of citalopram (Opra).
    • Evaluation of patient improvement rates.

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    Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint
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    Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint

    Published on: January 9, 2026

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    Last Updated: Jun 23, 2026

    A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
    04:38

    A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

    Published on: May 22, 2019

    Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint
    06:45

    Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint

    Published on: January 9, 2026

  • Monitoring for side effects, including impact on daily activities and cognitive functioning.

    • Main Results:

    • Citalopram (Opra) demonstrated significant improvement in 93.3% of patients with post-stroke depression.
    • The drug exhibited a notable anxiolytic effect.
    • Minimal side effects were observed, with no negative influence on daily activities or cognitive functioning.

    Conclusions:

    • Citalopram (Opra) is an effective and well-tolerated treatment for post-stroke depression.
    • The antidepressant and anxiolytic properties of citalopram contribute to improved patient outcomes.
    • Citalopram offers a favorable safety profile for stroke survivors experiencing depression.