Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Quantitative genetic variation and developmental clocks.

R Holliday1

  • 1CSIRO Laboratory for Molecular Biology, Division of Biomolecular Engineering, North Ryde, NSW, Australia.

Journal of Theoretical Biology
|August 7, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tooth wear time-bomb.

British dental journal·2026
Same author

Targeted periodontitis management in ACS patients.

British dental journal·2025
Same author

Misleading and worrying.

British dental journal·2023
Same author

Vaping misrepresentations.

British dental journal·2022
Same author

Waterline Disinfectants Reduce Dental Bioaerosols: A Multitracer Validation.

Journal of dental research·2022
Same author

Electronic cigarettes: an update on products, regulation, public health approaches and oral health.

Community dental health·2022
Same journal

An integrative model of FGF2-induced signaling and muscle cell proliferation.

Journal of theoretical biology·2026
Same journal

A Hybrid Reaction-Diffusion and Mechanical Stimulus Model for Mandibular Bone Remodeling under Chewing and Vibratory Loading.

Journal of theoretical biology·2026
Same journal

Integrated tick management strategies in fragmented peridomestic environments.

Journal of theoretical biology·2026
Same journal

Joint likelihood-free inference of the number of selected single nucleotide polymorphisms and their selection coefficients in an evolving population.

Journal of theoretical biology·2026
Same journal

Misspecification of the generation time distribution and its impact on R<sub>t</sub> estimates in structured populations.

Journal of theoretical biology·2026
Same journal

Stability-driven assembly meets Prigoginian informational dissipation. A mean-field ODE comment of entropy reduction and emergent proto-self.

Journal of theoretical biology·2026
See all related articles

Genetic variation significantly impacts quantitative traits. This study reveals a molecular mechanism involving DNA methylation and unequal sister chromatid exchange that explains unexpected variability in developmental clocks and quantitative traits.

Area of Science:

  • Evolutionary biology
  • Developmental biology
  • Genetics

Background:

  • Most genetic variation affects quantitative traits, influencing organismal features under selection.
  • Unexpectedly high variability exists even in inbred organisms, exceeding rates predicted by mutation alone.
  • Developmental clocks, potentially counting cell divisions, are hypothesized to control organismal size and shape.

Purpose of the Study:

  • To propose a molecular model for developmental clocks.
  • To explain the source of high genetic variability in quantitative traits.
  • To link DNA methylation, cell division, and evolutionary mechanisms.

Main Methods:

  • Molecular modeling of a developmental clock mechanism.
  • Analysis of DNA methylation in repeated sequences.

Related Experiment Videos

  • Consideration of unequal sister chromatid exchange in tandem repeats.

    • Main Results:

    • A model where DNA methylation of repeated sequences acts as a developmental clock tied to cell division.
    • Unequal sister chromatid exchange can alter the number of repeats, affecting clock length.
    • This mechanism provides a source for variation in quantitative traits.

    Conclusions:

    • The proposed molecular clock model explains high variability in quantitative traits.
    • Unequal sister chromatid exchange in developmental clock sequences drives evolutionary molecular drive.
    • This mechanism contributes to rapid adaptation and evolution of quantitative features.