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Are sex-biased genes more dispensable?

Judith E Mank1, Hans Ellegren

  • 1Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK. judith.mank@zoo.ox.ac.uk

Biology Letters
|May 13, 2009
PubMed

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Dosage Compensation

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In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
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The Ratio of X Chromosome to Autosomes

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