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Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Published on: June 3, 2019
PPARs: the vasculature, inflammation and hypertension
Sheng Zhong Duan1, Michael G Usher, Richard M Mortensen
1Nephrology Division, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109-0622, USA.
Current Opinion in Nephrology and Hypertension
|May 13, 2009
Summary
Peroxisome proliferator-activated receptors (PPARs) regulate inflammation and macrophage function. PPAR agonists show promise in treating hypertension, atherosclerosis, and metabolic disorders by modulating the immune system.
Area of Science:
- Molecular biology
- Immunology
- Cardiovascular medicine
Background:
- Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors activated by nutrients.
- PPARs play a crucial role in hypertension, metabolic disorders, and cardiovascular diseases like atherosclerosis.
- Modulating monocyte/macrophage phenotype is key to understanding PPAR agonist effects on inflammation.
Purpose of the Study:
- To review the role of PPARs in regulating innate inflammatory processes.
- To explore the impact of PPARs on monocyte/macrophage polarization.
- To assess the therapeutic potential of PPAR agonists in cardiovascular and metabolic diseases.
Main Methods:
- Literature review of studies on PPARs, inflammation, and cardiovascular disease.
- Analysis of research on PPARs' effects on macrophage polarization.
- Synthesis of findings regarding PPAR agonists in hypertension and metabolic syndrome.
Main Results:
- PPAR-gamma, PPAR-alpha, and PPAR-delta exhibit anti-inflammatory properties.
- PPARs are critical regulators of macrophage polarization, influencing cardiovascular disease progression.
- Inflammation is a significant factor in hypertensive disease damage.
Conclusions:
- PPARs likely play a unifying role in hypertension and its complications via immune system modulation.
- PPAR agonists may offer therapeutic benefits for hypertension, atherosclerosis, and obesity-related metabolic issues.
- Combination therapy with PPAR agonists and other anti-inflammatory drugs could be advantageous.
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