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Spitz nevus with an uncertain malignant potential.

Ligia Stănescu¹, Carmen Florina Popescu, Iuliana Georgescu

¹Pediatric Clinic, Filantropia University Hospital of Craiova, Craiova, Romania. ligstanescu@yahoo.com

Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie

|May 13, 2009

Summary

This summary is machine-generated.

This study details a rare case of Spitz nevus in a 10-year-old girl, initially stable but evolving after sun exposure. The diagnosis of Spitz nevus with uncertain malignant potential was confirmed by histopathology and immunohistochemistry.

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Area of Science:

Dermatology
Oncology
Pathology

Background:

Spitz nevi are benign melanocytic tumors often presenting in children.
Distinguishing Spitz nevi from melanoma can be challenging due to overlapping histological features.

Observation:

A 10-year-old girl presented with a tan, plane lesion on her upper lip, present since birth.
The lesion enlarged, changed shape, and bled after sun exposure and trauma at age 8.
Histopathology revealed features of both Spitz nevus and a melanocytic tumor with uncertain malignant potential, including atypical mitoses.

Findings:

Immunohistochemistry showed positivity for melanocytic markers (HMB45, Melan A) and CD44.
Low proliferation index (Ki67 < 5%) and rare cyclin D1 positivity were noted.
The final diagnosis was Spitz nevus with uncertain malignant potential.

Implications:

This case highlights the importance of comprehensive histopathological and immunohistochemical evaluation for accurate diagnosis of Spitz nevi.
Long-term clinical follow-up is crucial to rule out recurrence or metastasis in cases with uncertain malignant potential.
Understanding the evolution of Spitz nevi in response to environmental factors like sun exposure is important for clinical management.