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Related Experiment Video

Updated: Jun 23, 2026

Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration
13:17

Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration

Published on: May 26, 2014

Novel preparation techniques for controlling microbubble uniformity: a comparison.

Eleanor Stride1, Mohan Edirisinghe

  • 1Department of Mechanical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK. e_stride@meng.ucl.ac.uk

Medical & Biological Engineering & Computing
|May 13, 2009
PubMed
Summary
This summary is machine-generated.

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New methods for preparing microbubbles offer better control over size and uniformity for ultrasound drug delivery and imaging. These techniques show promise for enhanced therapeutic and diagnostic applications.

Area of Science:

  • Biomedical Engineering
  • Acoustic Imaging
  • Drug Delivery Systems

Background:

  • Coated microbubbles are increasingly used for ultrasound-mediated targeted drug delivery and advanced imaging.
  • Precise control over microbubble size, uniformity, and acoustic properties is crucial for efficacy and accurate dosing.
  • Existing preparation methods like sonication have limitations in achieving desired microbubble characteristics.

Purpose of the Study:

  • To compare the conventional sonication technique with coaxial electrohydrodynamic atomisation and microfluidic (T-junction) processing.
  • To evaluate these methods based on microbubble size, stability for in vivo use, uniformity, and production rates.
  • To assess practical and economic considerations for each microbubble preparation technology.

Main Methods:

Related Experiment Videos

Last Updated: Jun 23, 2026

Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration
13:17

Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration

Published on: May 26, 2014

  • Sonication: A conventional method for microbubble preparation.
  • Coaxial Electrohydrodynamic Atomisation: A recent technique utilizing electric fields for droplet formation.
  • Microfluidic (T-junction) Processing: An advanced method for controlled fluid mixing and droplet generation.

Main Results:

  • The study evaluated the ability of each method to produce small, stable microbubbles suitable for in vivo applications.
  • Uniformity of microbubble size and acoustic response was assessed across the different preparation techniques.
  • Relative production rates and other practical/economic factors were compared.

Conclusions:

  • The study provides a comparative analysis of microbubble preparation technologies for targeted drug delivery and imaging.
  • Findings will guide the selection of optimal methods for producing microbubbles with specific characteristics.
  • This research contributes to the advancement of ultrasound-mediated therapies and diagnostics through improved microbubble fabrication.