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Updated: Jun 23, 2026
In vivo Imaging of Fully Active Brain Tissue in Awake Zebrafish Larvae and Juveniles by Skull and Skin Removal
Published on: February 10, 2021
Real-time in vivo imaging of adult zebrafish brain using optical coherence tomography
K Divakar Rao1, Aneesh Alex, Yogesh Verma
1Laser Biomedical Applications & Instrumentation Division, Raja Ramanna Centre for Advanced Technology, Indore-452013, India. kdivakar@rrcat.gov.in
Abstract:
We report noninvasive imaging of the brain of adult zebrafish (Danio rerio) using real time optical coherence tomography (OCT) capable of acquiring cross sectional 2D OCT images @ 8 frames/sec. Anatomic features such as telencephalon, tectum opticum, eminentia Granularis and cerebellum were clearly resolved in the OCT images. A 3D model of zebrafish brain was reconstructed, for the first time to our knowledge, using these 2D OCT images.
