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Related Concept Videos

Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...

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Updated: Jun 23, 2026

Retroperitoneal Laparoscopic Debridement and Drainage for Pancreatic Abscess
03:42

Retroperitoneal Laparoscopic Debridement and Drainage for Pancreatic Abscess

Published on: March 15, 2024

[Advances in acute pancreatitis].

J Enrique Domínguez-Muñoz1

  • 1Servicio de Aparato Digestivo, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, España. enriquedominguezmunoz@hotmail.com

Gastroenterologia Y Hepatologia
|May 13, 2009
PubMed
Summary

Acute pancreatitis management is evolving, emphasizing persistent organ failure for severe cases. Early intervention with fluids and endoscopic treatments improves outcomes, shifting away from surgery for infected necrosis.

Area of Science:

  • Gastroenterology and Hepatology
  • Surgical Gastroenterology

Context:

  • Acute pancreatitis classification is shifting, with persistent organ failure now essential for defining severe disease.
  • Increased intestinal permeability is recognized as an early prognostic indicator in acute pancreatitis.

Purpose:

  • To review recent evidence on the definition, diagnosis, and treatment of acute pancreatitis.
  • To highlight advances in managing severe acute pancreatitis and its complications.

Summary:

  • Severe acute pancreatitis is defined by persistent organ failure; increased intestinal permeability is a key early sign.
  • Endoscopic ultrasonography is crucial for idiopathic or biliary pancreatitis.
  • Aggressive fluid resuscitation and conservative management, including endoscopic necrosectomy, are preferred for infected pancreatic necrosis.

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Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
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Last Updated: Jun 23, 2026

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Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
07:10

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

Published on: April 1, 2022

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
07:38

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Published on: May 10, 2024

Impact:

  • Updated understanding of acute pancreatitis severity criteria.
  • Improved diagnostic and treatment strategies for acute pancreatitis.
  • Evidence-based guidance on preventing post-ERCP pancreatitis.