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Updated: Jun 23, 2026

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
Published on: May 23, 2025
The Boston Ocular Surface Prosthesis as a novel drug delivery system for bevacizumab
Mira Lim1, Deborah S Jacobs, Perry Rosenthal
1Ophthalmic Education, Massachusetts Eye and Ear Infirmary, 243 Charles St., Boston, MA 02114, USA. mira_lim@meei.harvard.edu
Abstract:
Corneal neovascularization causes deterioration of visual acuity and increases surface irregularities. Various techniques have been employed to help control the progression of corneal neovascularization; bevacizumab is a medication that targets the specific pathway of corneal neovascularization. The Boston Ocular Surface Prosthesis (BOSP) is a large diameter contact lens that aids in maintaining corneal surface integrity and may serve as a delivery system for topical bevacizumab. This paper reviews five patients who were treated with topical bevacizumab in their BOSP. All patients demonstrated improvement in their visual acuity and clinical exam. No adverse reactions were noted.
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