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Updated: Jun 23, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
One-pot asymmetric synthesis of substituted piperidines by exocyclic chirality induction
Yunfeng Chen1, Cheng Zhong, Jeffrey L Petersen
1C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia 26506, USA.
Abstract:
A highly efficient one-pot synthesis of substituted piperidines was developed through nitroalkene, amine, and enone condensation. The transformation was suitable for a large group of substrates, giving excellent yields and diastereoselectivity. Reactions using chiral amines revealed a chirality induction through the unusual exocyclic stereochemistry control, producing enantiomeric pure piperidines in simple steps.
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