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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
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Related Experiment Video

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Induction and Analysis of Epithelial to Mesenchymal Transition
10:37

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

Towards understanding epithelial-mesenchymal transition: a proteomics perspective.

Rommel A Mathias1, Richard J Simpson

  • 1Joint Proteomics Laboratory, Ludwig Institute for Cancer Research and the Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

Biochimica Et Biophysica Acta
|May 15, 2009
PubMed
Summary

Proteomics reveals new insights into epithelial-mesenchymal transition (EMT), a process vital for embryonic development and cancer metastasis. Advanced proteomic techniques are refining our understanding of EMT and identifying novel proteins involved in this cellular transformation.

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Last Updated: Jun 23, 2026

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Published on: October 27, 2020

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Proteomics

Background:

  • Epithelial-mesenchymal transition (EMT) is a fundamental biological process essential for embryonic development.
  • EMT is increasingly recognized for its role in cancer progression and metastasis.
  • Traditional molecular and cell biology methods have limitations in fully elucidating EMT.

Purpose of the Study:

  • To review the significant contributions of proteomics to understanding EMT.
  • To highlight how proteomic techniques have identified novel proteins involved in EMT.
  • To discuss the impact of recent advances in proteomic methodologies on EMT research.

Main Methods:

  • Review of recent scientific literature focusing on proteomics and EMT.
  • Analysis of advancements in sub-proteome sample preparation.
  • Evaluation of new proteomic tools, including mass spectrometry and protein quantitation techniques.

Main Results:

  • Proteomics has significantly expanded the knowledge base of EMT.
  • Novel proteins implicated in EMT have been discovered through proteomic studies.
  • Integrated proteomic strategies offer deeper insights into EMT mechanisms.

Conclusions:

  • Proteomics is a powerful approach for studying EMT.
  • Advances in proteomic technologies promise to further refine our understanding of EMT.
  • Continued application of proteomics will be crucial for unraveling the complexities of EMT in development and disease.