Related Experiment Video
Updated: Jul 10, 2026

Feeding of Ticks on Animals for Transmission and Xenodiagnosis in Lyme Disease Research
Published on: September 1, 2013
Fatal case of deer tick virus encephalitis
Norma P Tavakoli1, Heng Wang, Michelle Dupuis
1Wadsworth Center, New York State Department of Health and the Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, New York, USA. norma.tavakoli@wadsworth.org
Abstract:
Deer tick virus is related to Powassan virus, a tickborne encephalitis virus. A 62-year-old man presented with a meningoencephalitis syndrome and eventually died. Analyses of tissue samples obtained during surgery and at autopsy revealed a widespread necrotizing meningoencephalitis. Nucleic acid was extracted from formalin-fixed tissue, and the presence of deer tick virus was verified on a flavivirus-specific polymerase-chain-reaction (PCR) assay, followed by sequence confirmation. Immunohistochemical analysis with antisera specific for deer tick virus identified numerous immunoreactive neurons, with prominent involvement of large neurons in the brain stem, cerebellum, basal ganglia, thalamus, and spinal cord. This case demonstrates that deer tick virus can be a cause of fatal encephalitis.
Related Concept Videos
Rocky Mountain Spotted Fever
Viral Meningitis
Rabies
Arboviral Encephalitis
Encephalitis l: Introduction
Encephalitis ll: Pathophysiology

