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Related Concept Videos

Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Intestinal Obstruction II: Pathophysiology01:07

Intestinal Obstruction II: Pathophysiology

Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...

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Related Experiment Video

Updated: Jun 23, 2026

Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia
08:55

Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia

Published on: May 18, 2018

[Chronic intestinal ischemia].

E S Debus1, B Luther, H Daum

  • 1Abt. Allgemein-, Gefäss- und Visceralchirurgie, Asklepios Klinik Harburg, Eissendorfer Pferdeweg 52, 21075 Hamburg, Deutschland. s.debus@asklepios.com

Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen
|May 15, 2009
PubMed
Summary
This summary is machine-generated.

Splanchnic artery disease, often insidious, carries a high mortality risk due to delayed diagnosis and treatment. Early detection through duplex sonography is crucial for managing chronic splanchnic ischemia.

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Last Updated: Jun 23, 2026

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Area of Science:

  • Vascular Surgery
  • Gastroenterology
  • Diagnostic Imaging

Context:

  • Ischemic lesions of splanchnic organs often present insidiously, leading to underestimation and delayed diagnosis.
  • High mortality rates (up to 90%) underscore the severity of splanchnic organ ischemia.
  • Increasing incidence linked to atherosclerosis progression and interventional vascular procedures.

Purpose:

  • To highlight the challenges in diagnosing and treating splanchnic organ ischemia.
  • To emphasize the importance of recognizing subtle symptoms of chronic splanchnic ischemia.
  • To advocate for the use of duplex sonography in assessing hemodynamic severity.

Summary:

  • Chronic splanchnic ischemia, a progressive condition often masked by collateralization, affects 1-2% of abdominal diseases.
  • Atherosclerosis and polymorbidity in an aging population contribute to its progression.
  • Duplex sonography offers critical insights into lesion severity, aiding timely intervention.

Impact:

  • Improved diagnostic strategies can reduce the high mortality associated with splanchnic ischemia.
  • Timely diagnosis and treatment can prevent dramatic disease progression.
  • Enhanced awareness and utilization of duplex sonography can improve patient outcomes.