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Updated: Jun 23, 2026

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
Published on: February 16, 2022
[Severe methemoglobinaemia following sodium nitrite ingestion]
Matthias Moos1, Ralph Schröder, Martin Lang
1Institut für Anästhesie und Reanimation am Kantonsspital Frauenfeld. matthias.moos@stgag.ch
Abstract:
We report the case of a patient suffering from a severe methemoglobinaemia following accidental sodium nitrite intoxication, a substance frequently used as a preservation agent for animal feed. On base of this case report, pathophysiology, clinical symptoms, diagnostical and therapeutical options with methylene blue (1-2 mg/kg of body weight) are discussed. Recently, pulse oximeters capable to measure 4 different hemoglobins have been introduced. These may be helpful for diagnosis especially in the prehospital setting.
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