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Related Experiment Video

Updated: Jun 23, 2026

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Tunable gel formation by both sonication and thermal processing in a cholesterol-based self-assembly system.

Junchen Wu¹, Tao Yi, Qian Xia

¹Department of Chemistry and Laboratory of Advanced Materials, Fudan University, 220 Handan Road, Shanghai 200433, China.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|May 15, 2009

Summary

New fluorescent organogelators self-assemble into gels using ultrasound or thermal stimuli. Their properties, including morphology and surface wettability, are tunable via alkyl chain length and environmental triggers.

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Last Updated: Jun 23, 2026

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

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Area of Science:

Supramolecular Chemistry
Materials Science

Background:

Development of novel organogelators is crucial for advanced materials.
Cholesterol-based molecules offer unique self-assembly properties.

Purpose of the Study:

To design and synthesize asymmetric cholesterol-based fluorescent organogelators.
To investigate their gelation capabilities and stimuli-responsive behavior.

Main Methods:

Synthesis of naphthalimide-containing cholesterol derivatives.
Solvent gelation studies with ultrasound and thermal stimuli.
Morphological analysis using microscopy (confocal, SEM, TEM).
Structural characterization via X-ray scattering and rheology.

Main Results:

Successful gelation of various organic solvents was achieved.
Gelling properties and morphology are dependent on alkyl chain length and stimuli.
Ultrasound and thermal stimuli significantly influence aggregation and nucleation processes.
Environmental stimuli control xerogel morphology and surface wettability.

Conclusions:

The designed organogelators exhibit tunable self-assembly and gelling properties.
Intermolecular interactions, modulated by stimuli, drive aggregation and morphology.
Provides insight into the gelation mechanism under ultrasound stimulus.