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Updated: Jun 23, 2026
Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles
Published on: January 22, 2015
Fabrication and characterization of chitosan-poly(acrylic acid) magnetic nanospheres
Yuqing Ge1, Song Zhang, Shiying He
1Jiangsu Laboratory for Biomaterials and Devices, State Key Laboratory of Bioelectronics, Department of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, P. R. China.
Abstract:
Iron oxide nanoparticles modified with meso-2,3-dimercaptosuccinic acid (DMSA), were encapsulated with a natural polymer with abundant primary amino groups, chitosan (CS), to improve their biocompatibility. Characterization was performed using Fourier transform infrared spectroscopy, thermogravimetirc analysis, transmission electron microscope analyses, vibrating sample magnetometer, zeta potential analyzer. It was found that highly ordered spherical aggregates with a mean diameter of 98 nm are obtained. The formation of aggregates depended on cross-linking of acrylic acid (AA) monomers and CS. These biodegradable CS-PAA polymer magnetic nanospheres might be useful for various biomedical applications.
