Related Experiment Video
Updated: Jun 23, 2026

Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
ING proteins in cellular senescence
Camino Menéndez1, María Abad, Daniel Gómez-Cabello
1Instituto de Investigaciones Biomédicas CSIC-UAM. Arturo Duperier, 4. 28029 Madrid, Spain.
Abstract:
Cellular senescence is an effective anti-tumor barrier that acts by restraining the uncontrolled proliferation of cells carrying potentially oncogenic alterations. ING proteins are putative tumor suppressor proteins functionally linked to the p53 pathway and to chromatin regulation. ING proteins exert their tumor-protective action through different types of responses. Here, we review the evidence on the participation of ING proteins, mainly ING1 and ING2, in the implementation of the senescent response. The currently available data support an important role of ING proteins as regulators of senescence, in connection with the p53 pathway and chromatin organization.
More Related Videos
08:52Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
Published on: April 6, 2022
13:59A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
Published on: August 12, 2018
Related Concept Videos
Negative Regulator Molecules
The Intrinsic Apoptotic Pathway
Replicative Cell Senescence
Replicative Cell Senescence
Bacterial Protein Maturation
Regulated Protein Degradation
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...