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Updated: Jun 23, 2026
06:35
An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
Giant cell tumour of bone
David M Thomas1, Keith M Skubitz
1Departments of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia. david.thomas@petermac.org
Current Opinion in Oncology
|May 16, 2009
Summary
Giant cell tumour of bone (GCT) is a common bone tumor. Denosumab, a new targeted therapy, shows an 86% response rate in unresectable GCT, offering a new treatment option.
Area of Science:
- Orthopedics
- Oncology
- Bone biology
Background:
- Giant cell tumour of bone (GCT) is the most common benign bone tumor, primarily affecting young individuals.
- Limited treatment options have been available for unresectable GCT for decades.
Purpose of the Study:
- To review recent advancements in understanding GCT pathogenesis.
- To evaluate novel therapeutic strategies for unresectable GCT.
Main Methods:
- Review of recent scientific literature focusing on GCT.
- Analysis of clinical trial data for denosumab in unresectable GCT.
Main Results:
- Receptor activator of nuclear factor kappa B ligand (RANKL) plays a crucial role in GCT development.
- Denosumab, a monoclonal antibody targeting RANKL, demonstrated an 86% response rate in a clinical trial for unresectable GCT.
- The drug was well-tolerated, showing significant clinical benefit.
Conclusions:
- Denosumab represents a promising new therapeutic option for patients with previously untreatable GCT.
- Ongoing research is exploring the role of denosumab and other targeted agents in GCT treatment.
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