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Updated: Jun 23, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

Eclampsia complicated by abdominal compartment syndrome.

Christine E Richter¹, Shelley Saber, Stephen F Thung

¹Department of Obstetrics, Yale University School of Medicine, New Haven, Connecticut, USA. christine.richter@yale.edu

American Journal of Perinatology

|May 16, 2009

Summary

A pregnant woman with HELLP syndrome developed abdominal compartment syndrome, necessitating surgery. This case highlights the critical need to consider abdominal compartment syndrome in pregnant patients with severe conditions.

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Published on: January 26, 2024

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Published on: June 6, 2020

Area of Science:

Obstetrics and Gynecology
Critical Care Medicine
Maternal-Fetal Medicine

Background:

Eclampsia is a severe complication of pregnancy characterized by seizures.
Hemolytic anemia, elevated liver enzymes, and low platelet count (HELLP) syndrome is a serious condition often associated with preeclampsia and eclampsia.
Intra-abdominal compartment syndrome (ACS) is a life-threatening condition involving increased intra-abdominal pressure.

Observation:

A primigravida patient presented with eclampsia and diagnosed with HELLP syndrome.
The patient subsequently developed signs and symptoms consistent with intra-abdominal compartment syndrome.
A decompressive laparotomy was required to manage the intra-abdominal hypertension.

Findings:

This case demonstrates a rare but critical progression from HELLP syndrome to intra-abdominal compartment syndrome in a pregnant patient.
The intra-abdominal hypertension significantly compromised organ function, necessitating surgical intervention.
Successful decompressive laparotomy relieved the pressure and addressed the acute complication.

Implications:

Clinicians should maintain a high index of suspicion for intra-abdominal compartment syndrome in pregnant women with severe conditions like eclampsia and HELLP syndrome.
Early recognition and management of intra-abdominal compartment syndrome are crucial for improving maternal outcomes.
This case underscores the importance of a comprehensive differential diagnosis in obstetric emergencies.