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Bronchitis (acute).

Peter Wark¹

¹Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, New Lambton, Australia.

BMJ Clinical Evidence

|May 19, 2009

Summary

This summary is machine-generated.

This systematic review found limited evidence for treatments of acute bronchitis in adults. Further research is needed to determine the effectiveness and safety of interventions like antibiotics and cough suppressants.

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Area of Science:

Respiratory Medicine
Clinical Evidence Synthesis

Background:

Acute bronchitis affects over 40/1000 UK adults annually, characterized by transient tracheal and bronchial inflammation.
Infective causes are suspected, yet pathogens are identified in only half of cases.
The influence of smoking on acute bronchitis susceptibility and recurrence remains unclear.

Purpose of the Study:

To systematically review the effects of various treatments for acute bronchitis in individuals without chronic respiratory conditions.
To evaluate the effectiveness and safety of common interventions for acute bronchitis.

Main Methods:

Conducted a systematic review of medical literature up to September 2007.
Searched major databases including Medline, Embase, and The Cochrane Library.
Included harms alerts from regulatory agencies like the FDA and MHRA.

Main Results:

Included 19 systematic reviews, randomized controlled trials (RCTs), and observational studies.
Performed a GRADE evaluation to assess the quality of evidence for different interventions.
Identified a range of interventions evaluated, including antibiotics, antihistamines, antitussives, beta(2) agonists, and analgesics.

Conclusions:

Presents information on the effectiveness and safety of reviewed interventions for acute bronchitis.
Highlights the need for careful consideration of treatment options due to varying evidence quality.
The review covers antibiotics (amoxicillin, cephalosporins, macrolides), antihistamines, antitussives, beta(2) agonists, expectorants, and analgesics.