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Inhaled Ciclesonide for Community-Based COVID-19: A Placebo-Controlled Randomised Trial.

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This summary is machine-generated.

Inhaled ciclesonide did not speed recovery from acute COVID-19 symptoms in a vaccinated population. Current evidence does not support using inhaled corticosteroids for COVID-19 treatment.

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Area of Science:

  • Respiratory Medicine
  • Infectious Diseases
  • Clinical Trials

Background:

  • Inhaled corticosteroids (ICS) have been explored for treating acute COVID-19 in the community.
  • Ciclesonide is an ICS investigated for its potential therapeutic effects.

Purpose of the Study:

  • To evaluate the efficacy and safety of daily inhaled ciclesonide (320 mcg) for 14 days in accelerating recovery from acute COVID-19 symptoms.
  • To compare recovery time and symptom duration between ciclesonide and placebo groups within 28 days.
  • To conduct a systematic review of ICS for acute COVID-19.

Main Methods:

  • A two-arm, double-blind, placebo-controlled, community-based randomized trial.
  • 189 participants received either inhaled ciclesonide or placebo for 14 days.
  • Primary outcome: time to first recovery from all symptoms; secondary outcomes included sustained recovery and respiratory symptoms.

Main Results:

  • No significant difference in the time to first recovery between ciclesonide and placebo groups (median 7 days, p=0.84).
  • Recovery rate ratio was 1.04 (95% CI; 0.77, 1.40).
  • No significant differences observed in secondary outcomes; treatment was safe and well-tolerated.

Conclusions:

  • In a highly vaccinated population (Omicron variants), inhaled ciclesonide did not accelerate recovery from acute COVID-19 symptoms.
  • Trial results and combined evidence do not support the use of inhaled corticosteroids for treating COVID-19.
  • Further research may be needed to explore ICS in different COVID-19 contexts or patient groups.