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Related Experiment Video

Updated: Jun 23, 2026

Development of a Virtual Reality Assessment of Everyday Living Skills

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Schizophrenia (maintenance treatment).

Thomas E Smith¹, Christi A Weston, Jeffrey A Lieberman

¹New York Presbyterian Hospital & Columbia University, New York, NY, USA.

BMJ Clinical Evidence

|May 19, 2009

Summary

This summary is machine-generated.

This review examines interventions for schizophrenia, finding that treatments like clozapine and family therapy can reduce relapse rates and improve outcomes for treatment-resistant patients. Adherence and negative symptoms remain challenges.

Related Experiment Videos

Last Updated: Jun 23, 2026

Development of a Virtual Reality Assessment of Everyday Living Skills

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Area of Science:

Psychiatry and Clinical Psychology
Evidence-Based Medicine
Pharmacology

Background:

Schizophrenia affects 1% of the population, with high relapse rates (75%) and significant disability.
A third of patients do not respond to standard treatments, highlighting a critical unmet need.
Negative symptoms of schizophrenia have proven particularly resistant to current interventions.

Purpose of the Study:

To systematically review interventions that reduce relapse and improve adherence in schizophrenia.
To identify effective treatments for individuals with schizophrenia resistant to standard antipsychotic drugs.

Main Methods:

A systematic review of 45 relevant studies including systematic reviews, RCTs, and observational studies.
Searches conducted across major databases (Medline, Embase, Cochrane Library) up to October 2007.
Inclusion of safety alerts from regulatory agencies (FDA, MHRA) and GRADE evaluation of evidence quality.

Main Results:

Evidence supports the effectiveness of various interventions for schizophrenia.
Specific treatments identified include clozapine, cognitive behavioral therapy (CBT), and family interventions.
Continuation of antipsychotic drugs is effective in reducing relapse rates.

Conclusions:

Multiple interventions show promise for improving schizophrenia outcomes, including relapse reduction and treatment resistance.
Clozapine, family interventions, and psychoeducational approaches are highlighted for their effectiveness.
Further research may be needed to address negative symptoms and long-term adherence.