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Updated: Jun 23, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
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Published on: November 5, 2019

Sickle cell disease.

Martin M Meremikwu1

  • 1Department of Paediatrics, College of Medical Sciences, University of Calabar, Calabar, Nigeria.

BMJ Clinical Evidence
|May 19, 2009
PubMed
Summary
This summary is machine-generated.

This systematic review examines interventions for sickle cell disease (SCD). It found various pharmaceutical and non-pharmaceutical treatments can prevent complications and manage pain in SCD patients.

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Area of Science:

  • Hematology
  • Clinical Medicine
  • Public Health

Background:

  • Sickle cell disease (SCD) is a genetic blood disorder causing chronic anemia, pain crises, and increased risk of stroke, organ damage, and infections.
  • In sub-Saharan Africa, SCD affects 1-2% of newborns, with up to 33% of adults being carriers of the sickle cell gene.

Purpose of the Study:

  • To systematically review the effectiveness and safety of pharmaceutical and non-pharmaceutical interventions for preventing sickle cell crisis and acute complications.
  • To evaluate interventions for treating pain during sickle cell crisis.

Main Methods:

  • A systematic review of 38 studies, including systematic reviews, randomized controlled trials (RCTs), and observational studies, was conducted.
  • Searches were performed in major databases (Medline, Embase, Cochrane Library) up to September 2007.
  • GRADE evaluation was used to assess the quality of evidence for interventions.

Main Results:

  • The review identified numerous interventions for sickle cell disease management.
  • Evidence quality was evaluated using the GRADE system.

Conclusions:

  • Information on the effectiveness and safety of 25 interventions is presented.
  • Interventions include antibiotic prophylaxis, hydroxyurea, vaccines, pain management strategies (e.g., morphine, paracetamol), and lifestyle modifications (e.g., hydration, avoidance of cold).