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Updated: Jun 23, 2026
05:21
A Luciferase-fluorescent Reporter Influenza Virus for Live Imaging and Quantification of Viral Infection
Published on: August 14, 2019
Summary
This systematic review examines influenza interventions, including vaccines and antiviral drugs like oseltamivir. It assesses their effectiveness and safety for preventing and treating seasonal influenza epidemics.
Area of Science:
- Public Health
- Infectious Diseases
- Epidemiology
Background:
- Influenza circulates seasonally, causing significant illness and epidemics.
- Population immunity influences influenza incidence and severity.
- Autumn-winter months are peak seasons for influenza transmission.
Purpose of the Study:
- To evaluate the effectiveness and safety of influenza vaccines.
- To assess antiviral chemoprophylaxis for influenza prevention.
- To determine the efficacy of antiviral medications in treating influenza.
Main Methods:
- Systematic review of scientific literature up to June 2008.
- Searched major databases including Medline and Embase.
- Included studies on vaccines, amantadine, oseltamivir, zanamivir, and rimantadine.
- Incorporated safety alerts from regulatory agencies like the FDA and MHRA.
Main Results:
- Identified 21 systematic reviews, RCTs, and observational studies.
- Evaluated the quality of evidence using the GRADE system.
- Compiled data on the effectiveness and safety of various influenza interventions.
Conclusions:
- Vaccines are a key intervention for preventing influenza.
- Antiviral medications (oseltamivir, zanamivir) show effectiveness in treatment.
- Amantadine and rimantadine have limited current utility due to resistance.
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