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Related Concept Videos

Pulmonary Embolism I: Introduction01:29

Pulmonary Embolism I: Introduction

Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
Pulmonary Embolism I: Introduction01:19

Pulmonary Embolism I: Introduction

A blood clot, or thrombus, is a semi-solid mass composed of fibrin, platelets, and red blood cells. When it forms within a vessel, it can obstruct blood flow, known as thrombosis. If part of the clot detaches, it becomes an embolus that can travel and block distant vessels. When this occurs in the pulmonary arteries, it causes a condition known as pulmonary embolism (PE).Origin and ImpactMost often, the embolus originates from a thrombus in the deep veins of the lower limbs, a condition called...
Venous Thrombosis I: Introduction01:30

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Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
Pulmonary Embolism III: Nursing Management01:27

Pulmonary Embolism III: Nursing Management

A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

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Related Experiment Video

Updated: Jun 23, 2026

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
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In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Published on: May 24, 2020

Thromboembolism.

Richard A McManus1, David Fitzmaurice, Ellen Murray

  • 1Department of Primary Care and General Practice, The Medical School, University of Birmingham, Birmingham, UK.

BMJ Clinical Evidence
|May 19, 2009
PubMed
Summary
This summary is machine-generated.

This systematic review evaluates treatments for deep vein thrombosis (DVT) and pulmonary embolism. It found various interventions like anticoagulation and compression stockings effective for managing these conditions.

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A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
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Last Updated: Jun 23, 2026

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
09:19

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A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

Area of Science:

  • Medical Research
  • Evidence-Based Medicine
  • Clinical Practice Guidelines

Background:

  • Deep vein thrombosis (DVT) and pulmonary embolism affect nearly 2 in 1000 people annually, with recurrence rates up to 25%.
  • Untreated DVT carries a 5-15% mortality risk from pulmonary embolism.
  • Key risk factors include immobility, surgery, malignancy, pregnancy, advanced age, and clotting disorders.

Purpose of the Study:

  • To systematically review the effectiveness and safety of various treatments for proximal DVT, isolated calf DVT, and pulmonary embolism.
  • To assess the impact of computerized decision support on oral anticoagulation management.
  • To synthesize evidence on interventions including anticoagulation, compression stockings, and thrombolysis.

Main Methods:

  • Conducted a systematic literature review searching major databases up to September 2007.
  • Included 40 systematic reviews, randomized controlled trials (RCTs), and observational studies.
  • Incorporated harms alerts from regulatory agencies like the FDA and MHRA.

Main Results:

  • Evaluated the quality of evidence for interventions using the GRADE system.
  • Identified multiple studies meeting inclusion criteria for analysis.
  • Synthesized data on a range of treatment modalities.

Conclusions:

  • Presents information on the effectiveness and safety of anticoagulation, compression stockings, and low molecular weight heparin.
  • Discusses findings related to oral anticoagulants, prolonged anticoagulation, thrombolysis, vena cava filters, and warfarin.
  • Provides a comprehensive overview of interventions for DVT and pulmonary embolism based on systematic review evidence.