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Chronic Inflammation: Introduction

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Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

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Updated: Jun 23, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Psoriasis (chronic plaque).

Luigi Naldi¹, Berthold Rzany

¹Ospedali Riuniti Bergamo, Bergamo, Italy.

BMJ Clinical Evidence

|May 19, 2009

Summary

This summary is machine-generated.

This systematic review evaluates various treatments for chronic plaque psoriasis, including systemic drugs, topical therapies, and ultraviolet light. It synthesizes evidence on effectiveness and safety to guide clinical decisions for psoriasis management.

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Measuring Psoriasis Severity at Home

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

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Last Updated: Jun 23, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Measuring Psoriasis Severity at Home

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Area of Science:

Dermatology
Evidence-based medicine
Systematic reviews

Background:

Psoriasis is a chronic skin condition affecting 1-3% of the population.
It can manifest as skin lesions, and in some cases, involve nails and joints.
Chronic plaque psoriasis is a common form requiring effective treatment strategies.

Purpose of the Study:

To systematically review the effectiveness and safety of various treatments for chronic plaque psoriasis.
To answer clinical questions regarding systemic, topical, non-drug, and ultraviolet light therapies.
To evaluate combined treatment modalities for psoriasis.

Main Methods:

Conducted a systematic review of medical literature up to August 2007.
Searched databases including Medline, Embase, and The Cochrane Library.
Included harms alerts from regulatory agencies like the FDA and MHRA.
Included 122 systematic reviews, RCTs, and observational studies.

Main Results:

Evaluated a wide range of interventions for chronic plaque psoriasis.
Included treatments such as systemic drugs (methotrexate, cyclosporine), topical agents (corticosteroids, vitamin D derivatives), and phototherapy (ultraviolet A, ultraviolet B).
Assessed combined therapies including drug plus ultraviolet light and systemic plus topical drug combinations.

Conclusions:

Presents information on the effectiveness and safety of numerous psoriasis interventions.
Covers treatments from acupuncture and balneotherapy to advanced biologics like etanercept and infliximab.
Provides a comprehensive overview to inform clinical practice for chronic plaque psoriasis management.