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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Postnatal depression.

Michael Craig1, Louise Howard

  • 1Health Services Research Department, Institute of Psychiatry, London, UK.

BMJ Clinical Evidence
|May 19, 2009
PubMed
Summary
This summary is machine-generated.

Postnatal depression affects 12-13% of women. This review evaluates drug and non-drug treatments for maternal depression, including cognitive behavioral therapy and SSRIs, to improve maternal mental health.

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Area of Science:

  • Perinatal mental health
  • Evidence-based medicine
  • Psychiatry

Background:

  • Postnatal depression (PND) affects 12-13% of women, similar to general depression prevalence.
  • Unique treatment challenges exist for nursing mothers with PND.
  • Suicide is a leading cause of maternal mortality in developed nations, though postpartum rates are lower.

Purpose of the Study:

  • To systematically review the effects of drug and non-drug treatments for postnatal depression.
  • To answer clinical questions regarding the efficacy and safety of various PND interventions.

Main Methods:

  • Systematic review of 34 studies (reviews, RCTs, observational studies) up to May 2008.
  • Searched Medline, Embase, Cochrane Library, and other databases.
  • Included harms alerts from FDA and MHRA.

Main Results:

  • Evaluated the quality of evidence for interventions using GRADE methodology.
  • Identified numerous interventions for PND, including pharmacological and psychological therapies.
  • Data synthesis focused on effectiveness and safety of treatments.

Conclusions:

  • Information on effectiveness and safety of interventions for PND is presented.
  • Interventions reviewed include group and individual CBT, SSRIs, St John's Wort, interpersonal psychotherapy, light therapy, and more.
  • This review provides a comprehensive overview of treatment options for postnatal depression.