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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

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Published on: April 28, 2019

Dengue haemorrhagic fever or dengue shock syndrome in children

Marissa M Alejandria1

  • 1Section of Infectious Diseases, Departments of Medicine and Clinical Epidemiology College of Medicine, University of the Philippines, Manila, The Philippines.

BMJ Clinical Evidence
|May 19, 2009
PubMed

Insights

This systematic review examines supportive treatments for dengue hemorrhagic fever and dengue shock syndrome in children. Evidence on interventions like fluid therapy and blood components is evaluated for effectiveness and safety.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Dengue hemorrhagic fever and dengue shock syndrome are significant causes of pediatric hospitalizations and mortality.
  • Mortality rates can reach up to 5% without adequate supportive care.

Purpose of the Study:

  • To systematically review the effects of supportive treatments for dengue hemorrhagic fever or dengue shock syndrome in children.
  • To evaluate the effectiveness and safety of various interventions.

Main Methods:

  • Conducted a systematic review of studies including systematic reviews and randomized controlled trials (RCTs).
  • Searched major databases (Medline, Embase, Cochrane Library) up to June 2008.
  • Included harms alerts from regulatory agencies (FDA, MHRA).

Main Results:

  • Included 13 systematic reviews or RCTs meeting the inclusion criteria.
  • Performed a GRADE evaluation to assess the quality of evidence for interventions.

Conclusions:

  • Presents information on the effectiveness and safety of interventions for pediatric dengue hemorrhagic fever and dengue shock syndrome.
  • Evaluated treatments include blood component transfusion, carbazochrome sodium sulfonate, corticosteroids, intravenous immunoglobulin, recombinant-activated factor VII, colloids, crystalloids, and intravenous fluids.
Abstract

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