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Updated: Jun 23, 2026

An Ex Vivo Model of Ovarian Cancer Peritoneal Metastasis Using Human Omentum
05:42

An Ex Vivo Model of Ovarian Cancer Peritoneal Metastasis Using Human Omentum

Published on: January 26, 2024

Ovarian cancer (advanced).

Sean Kehoe1, Jo Morrison

  • 1Nuffield Department of Obstetrics and Gynaecology, Women's Centre, John Radcliffe Hospital, Oxford, UK.

BMJ Clinical Evidence
|May 19, 2009
PubMed
Summary

This systematic review evaluates surgical and chemotherapy treatments for advanced ovarian cancer. It synthesizes evidence on platinum-based, taxane-based, and intraperitoneal chemotherapy, alongside surgical interventions, to inform treatment decisions.

Area of Science:

  • Oncology
  • Gynecologic Oncology
  • Evidence-Based Medicine

Background:

  • Ovarian cancer is a leading cause of cancer mortality in the UK.
  • Survival rates for ovarian cancer vary significantly with age at diagnosis.
  • Advanced ovarian cancer presents a significant clinical challenge.

Purpose of the Study:

  • To systematically review the effects of surgical treatments for advanced ovarian cancer.
  • To assess the efficacy and safety of platinum-based and taxane-based chemotherapy regimens.
  • To evaluate the role of intraperitoneal chemotherapy in advanced ovarian cancer management.

Main Methods:

  • Systematic literature search of major databases (Medline, Embase, Cochrane Library) up to September 2007.
  • Inclusion of 31 systematic reviews, randomized controlled trials (RCTs), and observational studies.

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  • Inclusion of safety data from regulatory agencies (FDA, MHRA).

    • Main Results:

    • Evidence was evaluated using the GRADE system for quality assessment.
    • The review synthesized data on various chemotherapy combinations and surgical procedures.
    • Effectiveness and safety data for multiple interventions were compiled.

    Conclusions:

    • The review provides comprehensive information on interventions for advanced ovarian cancer.
    • Key interventions discussed include platinum-taxane combinations, intraperitoneal chemotherapy, and surgical approaches.
    • Findings support informed decision-making regarding treatment options for advanced ovarian cancer.