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Angina (chronic stable)

Laurence O'Toole1

  • 1Dept of Cardiology, Royal Hallamshire Hospital, Sheffield, UK.

BMJ Clinical Evidence
|May 19, 2009
PubMed

Insights

Long-term drug treatments for stable angina, including beta-blockers and calcium channel blockers, were reviewed for effectiveness and safety. This systematic review provides evidence on various anti-anginal therapies.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Stable angina, often caused by coronary atherosclerosis, affects a significant percentage of older adults.
  • Key risk factors include hypertension, high cholesterol, smoking, inactivity, and obesity.
  • Angina patients face elevated risks of cardiovascular events and mortality.

Purpose of the Study:

  • To systematically review the long-term effects of drug treatments for stable angina.
  • To evaluate the effectiveness and safety of various anti-anginal interventions.

Main Methods:

  • A systematic review was conducted, searching major medical databases up to June 2007.
  • Included studies were systematic reviews, randomized controlled trials (RCTs), and observational studies.
  • Evidence quality was assessed using the GRADE system, incorporating safety alerts from regulatory agencies.

Main Results:

  • Nine studies met the inclusion criteria for the review.
  • The review analyzed data on beta-blockers, calcium channel blockers, long-acting nitrates, and potassium channel openers.
  • Effectiveness and safety data for combination therapies and adjunct treatments were also examined.

Conclusions:

  • The review provides comprehensive information on the long-term effectiveness and safety of multiple anti-anginal drug classes.
  • Evidence supports the use of beta-blockers, calcium channel blockers, and other agents in managing stable angina.
  • Findings guide clinical decisions regarding anti-anginal drug therapy and adjunct treatments.
Abstract

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