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Updated: Jun 23, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

Acute renal failure.

John A Kellum¹, Martine Leblanc, Ramesh Venkataraman

¹Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, USA.

BMJ Clinical Evidence

|May 19, 2009

Summary

This systematic review evaluates interventions for preventing and treating acute kidney injury (AKI). It found 77 studies on treatments like albumin, diuretics, and dialysis, assessing their effectiveness and safety in high-risk patients.

Area of Science:

Nephrology
Critical Care Medicine
Evidence-Based Medicine

Background:

Acute renal failure, now termed acute kidney injury (AKI), involves a rapid decline in kidney function, leading to toxin buildup.
AKI severity is classified using RIFLE criteria based on serum creatinine and urine output changes.

Purpose of the Study:

To systematically review interventions for preventing AKI in high-risk individuals.
To assess treatments for critically ill patients with established AKI.

Main Methods:

Conducted a systematic review of studies up to April 2007.
Included systematic reviews, randomized controlled trials (RCTs), and observational studies.
Incorporated safety alerts from regulatory agencies like the FDA and MHRA.

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Main Results:

Identified 77 relevant studies meeting inclusion criteria.
Performed GRADE evaluations to assess the quality of evidence for interventions.
Compiled data on the effectiveness and safety of various AKI interventions.

Conclusions:

Presents findings on interventions including albumin, diuretics, N-acetylcysteine, and renal replacement therapy.
Provides information on the effectiveness and safety of treatments for acute kidney injury.
Highlights the need for evidence-based approaches in managing AKI.