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Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
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Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease
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Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

Published on: September 5, 2025

Chronic fatigue syndrome.

Steven F Reid1, Trudie Chalder, Anthony Cleare

  • 1Imperial College, St Mary's Hospital, London, UK.

BMJ Clinical Evidence
|May 19, 2009
PubMed
Summary
This summary is machine-generated.

This review examines treatments for Chronic Fatigue Syndrome (CFS), finding evidence on antidepressants, cognitive behavioral therapy (CBT), graded exercise, and others. Safety and effectiveness data guide clinical decisions for CFS patients.

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Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
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Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
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Published on: May 17, 2018

Area of Science:

  • Medical Research
  • Systematic Review
  • Clinical Evidence

Background:

  • Chronic Fatigue Syndrome (CFS) impacts 0.006% to 3% of the population.
  • Women are disproportionately affected by CFS.
  • Prevalence varies based on diagnostic criteria.

Purpose of the Study:

  • To systematically review treatments for Chronic Fatigue Syndrome (CFS).
  • To evaluate the effectiveness and safety of various CFS interventions.
  • To answer the clinical question: What are the effects of CFS treatments?

Main Methods:

  • Systematic literature search of Medline, Embase, and Cochrane Library up to September 2007.
  • Inclusion of 45 systematic reviews, RCTs, and observational studies.
  • GRADE evaluation of evidence quality for interventions.
  • Inclusion of harms alerts from regulatory agencies (FDA, MHRA).

Main Results:

  • Identified 45 studies meeting inclusion criteria for CFS treatments.
  • Evaluated evidence quality using the GRADE system.
  • Compiled data on a range of interventions for CFS.

Conclusions:

  • Presents information on the effectiveness and safety of numerous CFS interventions.
  • Interventions reviewed include antidepressants, CBT, graded exercise therapy, and more.
  • Provides a comprehensive overview of current evidence for CFS treatments.