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Related Concept Videos

Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...

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A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology
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Published on: June 3, 2014

Biaxial cell stimulation: A mechanical validation.

F H Bieler1, C E Ott, M S Thompson

  • 1Julius Wolff Institut and Center for Musculoskeletal Surgery, Berlin/Brandenburg Center for Regenerative Therapies, Charité - Universitätsmedizin Berlin, 13353 Berlin, Germany.

Journal of Biomechanics
|May 19, 2009
PubMed
Summary
This summary is machine-generated.

This study found that in vitro cell stimulation devices apply consistent strain but transfer only half to cells. Device material degrades with use, affecting strain accuracy.

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Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Mechanical Engineering

Background:

  • In vitro cell stimulation devices are crucial for studying mechanotransduction.
  • Understanding strain distribution and transfer is vital for accurate experimental results.
  • Commercial devices require validation for reliable mechanobiology research.

Purpose of the Study:

  • To quantify strain distribution and consistency in a commercial cell stimulation device.
  • To measure the strain transferred from the device membrane to adherent bone marrow-derived cells.
  • To assess the impact of cyclic loading on device performance and material integrity.

Main Methods:

  • Digital Image Correlation (DIC) was used to analyze strain distribution within the device.
  • Fluorescence microscopy of eGFP-transfected cells tracked strain transfer.
  • Cellular coordinate analysis quantified strain experienced by bone marrow-derived cells.

Main Results:

  • The device exhibited homogeneous and reproducible strain in the central area.
  • Bone marrow-derived cells received approximately 50% of the applied strain.
  • Device membrane Young's modulus decreased with increased cycling, indicating material degradation.

Conclusions:

  • Commercial cell stimulation devices provide reliable strain application but reduced transfer to cells.
  • Material degradation occurs with prolonged use, altering strain magnitudes.
  • Experimental results from these devices necessitate careful interpretation, particularly at higher cycle numbers.