Context dependent effects of ventral tegmental area inactivation on spatial working memory
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Updated: Jun 23, 2026

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze
Published on: July 29, 2025
Adria K Martig1, Graham L Jones, Kelsey E Smith
1Psychology Department, Box 351525, University of Washington, Seattle, WA 98195-1525, United States.
Abstract:
Rats were tested on a hippocampus dependent win-shift working memory task in familiar or novel environments after receiving bilateral ventral tegmental area infusions of baclofen. Baclofen infusion disrupted working memory performance in both familiar and novel environments. In addition, baclofen infusion selectively disrupted short-term working memory in the novel environment. This experiment confirms selective ventral tegmental area support of accurate performance during a context dependent spatial navigation task.
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