The mouse resources at the RIKEN BioResource center

Area of Science:

• Life Sciences
• Biomedical Research
• Genetics

Background:

• Mice are crucial model organisms in life sciences for studying diseases.
• Large-scale knockout mouse projects are vital for biomedical research.
• RIKEN BRC, established in 2001, serves as a core facility for Japan's National BioResource Project (NBRP).

Purpose of the Study:

• To highlight the role and resources of RIKEN BRC in supporting global biomedical research.
• To detail the collection, characterization, and distribution of diverse mouse strains.
• To emphasize RIKEN BRC's commitment to providing high-quality, accessible mouse models.

Main Methods:

• Collection and curation of over 3,800 mouse strains (inbred, transgenic, knockout, etc.).
• Rederivation of mice to specific pathogen-free (SPF) status.
• Rigorous health monitoring, genetic testing, and cryopreservation of mouse resources.
• Participation in international collaborations like the Federation of International Mouse Resources (FIMRe) and International Mouse Strain Resource (IMSR).

Main Results:

• RIKEN BRC distributes a wide array of mouse models, including those for human diseases and gene function studies.
• Mouse strains are rederived, health-monitored, and genetically validated to meet research needs.
• Global accessibility is facilitated through online platforms and international resource sharing.

Conclusions:

• RIKEN BRC is a key global resource for high-quality mouse models, supporting diverse biomedical research.
• International collaboration ensures worldwide access to valuable mouse strains.
• Efficient preservation methods like cryopreservation safeguard these critical research resources.