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Updated: Jun 23, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
Published on: September 20, 2018
Chromatin-level regulation of biosynthetic gene clusters
Jin Woo Bok1, Yi-Ming Chiang, Edyta Szewczyk
1Department of Medical Microbiology and Immunology (formerly Department of Plant Pathology), University of Wisconsin-Madison, Madison, Wisconsin, USA.
Abstract:
Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone H3 lysine 4 methylation, activated the expression of cryptic secondary metabolite clusters in A. nidulans. One new cluster generated monodictyphenone, emodin and emodin derivatives, whereas a second encoded two anti-osteoporosis polyketides, F9775A and F9775B. Modification of the chromatin landscape in fungal secondary metabolite clusters allows for a simple technological means to express silent fungal secondary metabolite gene clusters.
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